If a woman with an unknown family history has an early-onset breast cancer or ovarian cancer or a man with an unknown family history is diagnosed with breast cancer, that individual may want to consider genetic counseling and testing for a BRCA1 or BRCA2 mutation. BRCA Mutations. A BRCA mutation occurs when the DNA that makes up the gene becomes damaged in some way. When a BRCA gene is mutated, it may no longer be effective at repairing broken DNA and helping to prevent breast cancer. Because of this, people with a BRCA gene mutation are more likely to develop breast cancer.
When someone with a cancer diagnosis and a family history of the disease has been tested and found to have an altered BRCA1 or BRCA2 gene, the family is said to have a "known mutation.". If an association between the development of breast cancer and a breast cancer gene is made. BRCA1 and BRCA2 (BReast CAncer genes 1 and 2) are the best-known genes linked to breast cancer risk. This section provides information on BRCA1/2 gene mutations and how they impact cancer risk, breast cancer screening recommendations and options for lowering breast cancer risk. It also has information on genetic testing and other topics.
Mar 20, 2019 · In addition to the often talked about BRCA gene mutations, there are a significant number of other inherited gene mutations that increase the risk of developing breast cancer. In fact, it's thought that mutations in over 72 genes contribute to risk, and the number of non-BRCA gene mutations that raise breast cancer risk is expected to grow as our knowledge of the genetics of cancer .