Nov 21, 2018 · Macrophage activation syndrome (MAS) is a life-threatening complication of rheumatic disease that, for unknown reasons, occurs much more frequently in individuals with systemic juvenile idiopathic arthritis (SJIA) and in those with adult-onset Still disease. Macrophage activation syndrome is characterized by pancytopenia, liver insufficiency. Overproduction of interleukin (IL)-18 is closely related to the pathogenesis of adult-onset Still's disease (AOSD) and the development of macrophage activation syndrome (MAS), a life-threating complication of AOSD. We reported three cases of MAS occurring in infants born to mothers with AOSD.Author: Masaki Shimizu, Toshitaka Kizawa, Ryota Kato, Takayuki Suzuki, Akihiro Yachie.
Macrophage-activation syndrome is a severe, potentially life-threatening, complication of several chronic rheumatic diseases of childhood. It occurs most commonly with systemic-onset juvenile idiopathic arthritis (SoJIA). In addition, MAS has been described in association with systemic lupus erythematosus (SLE), Kawasaki disease, and adult-onset Still's disease.Other names: MAS. We report the case of a 71-year-old Japanese woman with adult-onset Still's disease (AOSD) in whom macrophage activation syndrome (MAS) developed despite therapy with oral high-dose prednisolone and intravenous methylprednisolone pulse therapy twice. She was successfully treated with tocilizumab Cited by: 9.
In neonatal lupus, macrophage activation syndrome (MAS) is very rare. Now, we reported a newborn infant with MAS born from a untreated mother with adult onset Still disease. We reported a newborn infant with macrophage activation syndrome (MAS) born from a Author: Jung Woo Rhim, Soo Young Lee, Joo Hyung Park, Soon Joo Lee, So Young Kim, Dae-Chul Jeong. Macrophage activation syndrome (MAS) is the term used to describe a potentially life-threatening complication of rheumatic diseases, which is seen most frequently in systemic juvenile idiopathic arthritis (sJIA) and in its adult equivalent, adult-onset Still's disease [1–4], although it is encountered with increasing frequency in systemic.